Substrate regulation of vascular endothelial cell morphology and alignment

Dynamic Regulation of Vascular Permeability by Vascular Endothelial Cadherin-Mediated Endothelial Cell-Cell Junctions.

Endothelial cells lining blood vessels regulate vascular barrier function, which controls the passage of plasma proteins and circulating cells across the endothelium. In most normal adult tissues, endothelial cells preserve basal vascular permeability at a low level, while they increase permeability in response to inflammation. Therefore, vascular permeability is tightly controlled by a number ...

Transcriptional regulation of endothelial cell and vascular development.

The establishment and maintenance of the vascular system is critical for embryonic development and postnatal life. Defects in endothelial cell development and vessel formation and function lead to embryonic lethality and are important in the pathogenesis of vascular diseases. Here, we review the underlying molecular mechanisms of endothelial cell differentiation, plasticity, and the development...

Differential Regulation of Vascular Smooth Muscle and Endothelial Cell Proliferation

37 cAMP inhibits proliferation in most cell types triggering different and sometimes opposing 38 molecular pathways. p85α (PI3K regulatory subunit) is phosphorylated by cAMP/PKA in certain 39 cell lineages but its effects on vascular smooth muscle cells (VSMCs) and endothelial cells (ECs) 40 are unknown. In the present study we evaluated: i) the role of p85α in the integration of 41 cAMP/PKA-de...

Endothelial regulation of vascular tone.

Vascular Endothelial Growth Factor in Serum and Saliva of Oral Lichen Planus and Oral Squamous Cell Carcinoma Patients

Background:Oral lichen planus (OLP) is considered as a potentially malignant disorder and vascular endothelial growth factor (VEGF) may play a key role in cancer development. The aim of this study was to compare serum and saliva VEGF among patients with OLP, oral squamous cell carcinoma (OSCC) and a healthy control group. Methods:A cross sectional study was pe...